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Emerg Infect Dis
; 28(11): 2350-2352, 2022 Nov.
Article
in English
| MEDLINE | ID: covidwho-2054902
ABSTRACT
A heterozygous nonsense variant in the TIGIT gene was identified in a patient in Thailand who had severe COVID-19, resulting in lower TIGIT expression in T cells. The patient's T cells produced higher levels of cytokines upon stimulation. This mutation causes less-controlled immune responses, which might contribute to COVID-19 severity.